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Gastrointestinal disturbances, constipation, dyslipidemia, and micronutrient deficiencies are common side effects in the KD regimen which is often discontinued earlier than recommended because such symptoms are difficult to be controlled 6

I high dose on b1 but that's again, because I am deficient in that and didn't start that until I had done the b12 for about 1.5 years

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For example, with semaglutide (Ozempic), the recommended titration schedule for type 2 diabetes involves starting with a 0.25 mg dose once weekly for four weeks, followed by an increase to 0.5 mg once weekly for at least four weeks

The second reason may be that plant adaptability stabilized the working efficiency of GPX, which lead to post-transcriptional regulation, thus reducing the activity of GPX enzyme [21,22,23]

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