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BrllVBurakCStoffel-WagnerBWolfframSNickenigGMllerCet alEffects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: a randomised double-blinded placebo-controlled cross-over trial

From these results we can assume ozone therapy influenced positively the synthesis and release of cytokines (14,15) in such away that a change from Th2 to Th1 [IL-2, IFNg] pattern occurs, reducing the production of asthma mediators [IgE, HLA-DR, etc]

At the same time, it is very gentle, so I havent experienced any irritation

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CRC, Boca Raton, pp 105116 Lu SC (2009) Regulation of glutathione synthesis

Nature 380 , 364366 (1996)