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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

Why HbA1c May Be Unreliable in B12 Deficiency B12 deficiency alters red cell turnover and erythropoiesis, making HbA1c potentially unreliable in either direction the distortion is variable and cannot be predicted

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Treatment of migraine: update on new therapies