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Yes intranasal dihexa produces a systemic plasma half life of one to two hours (similar to intraperitoneal), but CNS tissue half life is extended to four to six hours because the peptide is transported directly to the brain along olfactory and trigeminal nerve pathways, bypassing blood-brain barrier penetration and hepatic first-pass metabolism
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Gebre-Medhin, S., Mulder, H., Zhang, Y., Sundler, F
Some preliminary studies in rats showed possible benefits for tendon healing, but we don't have enough research to know if it helps chronic tendon injuries in humans
The motor-clutch model predicts that cells generate maximal traction force at intermediate stiffness [92]