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These platforms collectively advance therapeutic precision by integrating biosensing, self-regulated enzyme activity, and biomimetic catalysis, addressing critical limitations of traditional urate-lowering therapies

Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes

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X.ChenC.LiuY.et al (2019)

It inhibits NF-kB, the master transcription factor controlling the inflammatory cascade, and is actively transported into inflamed intestinal cells via the PepT1 transporter

Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction