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Severe gastrointestinal disease, particularly gastroparesis, may alter both efficacy and tolerability and requires careful consideration

doi: 10.1038/s41591-022-02026-4 Jastreboff AM, Aronne LJ, Ahmad NN, et al

In this study, all plausible metabolites in the urine, feces and bile were screened and compared with the profiles of the blank urine, feces and bile and samples collected before administration

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The proposed mechanism combines improved blood flow and tissue oxygenation with reduced post-exercise hypoxia which translates into less extensive micro-damage and more efficient reconstruction