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The other two are comparative : He chose tirzepatide over pure GLP-1 (semaglutide) based partly on the SURPASS-CVOT trial, which showed tirzepatide performed at least as well as dulaglutide (a GLP-1 agonist) on cardiovascular outcomes, with a post-hoc analysis suggesting a 16% risk reduction on a broader six-component endpoint

Resources We Trust Mayo Clinic: Considering GLP-1 Medications

Only 5% of Diabetes sufferers have Type 1 today

We observed a significant increase (60%) in hexokinase activity in the GK rat liver, which remained higher than control levels even after exercise (Figure 4A)

The same hormonal signaling that suppresses appetite and drives weight loss also accelerates colonic transit and increases water secretion in the lower bowel, especially during the first few weeks of treatment and after each dose increase