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doi:10.3390/ijms26062691 Gatta M, Dovizio M, Milillo C, et al

Search Strategy A comprehensive literature search was conducted using the National Library of Medicine database (www.pubmed.ncbi.nlm.nih.gov ) without applying any language or publication date restrictions

Thyroid Tumors: Rodent Risk, Human Precaution In animal studies, GLP-1s have been linked to C-cell tumors of the thyroid, including medullary thyroid carcinoma (MTC)

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In diet-induced obese (DIO) mouse models, 5-Amino-1MQ treatment produced significant reductions in body weight, white adipose tissue mass, and adipocyte cell size without significant effects on food intake suggesting a metabolic rather than appetite-suppressing mechanism

If any abnormal features of the cells are found such as damages in a plastic envelop of the cell, deformation of the cell package, smelling of electrolyte, electrolyte leakage and others, the cells shall never be used any more