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National Library of Medicine, the average smoking rate in Middle Eastern countries is 45 percent for adult males and 5 percent for females

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Moreover, the RR for the heavy alcohol and heavy smoking group was 35.24 (95% CI, 23.1753.58), which was much higher than those of the heavy alcohol and non-smoking group and non-alcohol and heavy smoking group, indicating a multiplicative interaction

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2.3 on General principles of disease classification started with this 1856 statement by William Farr: Classification is a method of generalization

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