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VEGF-A is upregulated due to MDS and partially contributes to the vascular changes in DR by altering the blood vessel permeability and promoting neovascularization

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This inverse relationship highlights a potential neurovascular mechanism by which excessive GABAergic inhibition may reduce metabolic activity and impair cortical connectivity, further exacerbating PTSD symptoms

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1 Introduction Diabetes is a multifaceted condition that fundamentally disrupts metabolic homeostasis