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Introducing nicotine to the brain 10 years prior to that, without speaking of the massive amount of nicotine contained in each cartridge, will undoubtedly alter that developing brain. Looking beyond nicotine, using e-cigarettes Juul or otherwise comes with many health risks, including the possibility for seizures, heart attacks, lung damage and birth defects

StatPearls, Treasure Island Okorare O, Evbayekha EO, Adabale OK, Daniel E, Ubokudum D, Olusiji SA, Antia AU (2023) Smoking cessation and benefits to cardiovascular health: a review of literature

ELISA ELISA of supernatant IL-1 (BD Biosciences, NJ, USA) was conducted according to the instructions of the manufacturer