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Unexpectedly, activation of p21, ICAM1, or SRXN1 was not observed (Supplementary Figure S5), although DNA ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study ( Figure 7 , AQ-QI and DEAQ-QI exposure resulted in activation of the ER stress response

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Excessive ROS accumulation leads to oxidative stress

Sulforaphane, a bioactive compound derived from broccoli, reduces oxidative stress, too

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