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In addition, we performed validation analyses using the MELODI Presto platform 41 , to externally validate findings from prior studies and confirm the identified mediators

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It also addresses strategies for targeting the gut microbiota that contribute to the generation of TMAO for the potential prevention and treatment of CVD as well as the role of gut microbiota in CVD and potential corresponding interventions

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15,34,62 Protect against further nerve damage - by reducing oxidative stress & pro-inflammatory markers

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