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Our findings provide new evidence that nicotine type and concentration modify the adverse cardiovascular effects of e-cigarette aerosols, which may have important regulatory implications. The study also revealed that the higher levels of nicotine salts increased sympathetic nervous system activity, also known as the fight-or-flight response, by stimulating the same receptor that is inhibited by beta-blockers, heart medications that are prescribed to treat cardiac arrhythmias

Association between current e-cigarettes users and risk of COPD The meta-analysis demonstrated a statistically significant association between current e-cigarette use and the odds of having COPD, with a pooled OR of 1.473 (95% CI: 1.2601.723)