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Minnesota Minnesota mandates retailer licensing ($1,000 annually) and has raised taxes to 55% of the wholesale price in 2025

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These include nicotine replacement therapy (patch, gum, lozenge, inhaler, nasal spray) and prescription medicines such as varenicline and bupropion SR

Nrf2 is a transcription factor that regulates gene expression following its binding to antioxidant responsive elements and activates anti-oxidant genes [36]

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