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Dosage should start at 1 g/day, (10 mL/day), and be increased slowly while assessing tolerance and therapeutic response

Measurable changes in IGF-1 levels take 4 to 12 weeks

It inhibits the activation of the NLRP3 inflammasome, regulates the TNF signaling pathway and Th17 cell differentiation, and reduces the expression of pro-inflammatory factors IL-1, IL-18 as well as pulmonary vascular remodeling-related factors MMP-2, MMP-9, Collagen one and Collagen 3, thereby alleviating PAH (Xin et al., 2020)

Accumulating evidence suggests that semaglutide may be of benefit for managing MASH due to its ability to help manage cardiometabolic risk factors, ease inflammation, lower liver fat, and prevent fibrosis progression