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The mechanisms behind this condition have not been universally accepted yet [8]

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[55] This downregulation restores normal leptin signaling pathways (such as the JAK/STAT cascade), effectively re-establishing proper appetite control and reducing energy intake

Brtsch SH, Wang CC, Li L, Stender H, Neziroglu N, Richter C et al (2015) Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice

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