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Elevation of ROS levels results in oxidative stress in airway epithelial cells which activates an antioxidant defence mechanism known as the Keap1Nrf2 pathway to counteract the harmful effects of oxidative stress (Schieber and Chandel 2014)

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With departures, that pretty much cancels out your smoking zones

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ZYN contains nicotine, which is addictive regardless of delivery method