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L-carnitine reverses methotrexateinduced nephrotoxicity in experimental rat model: insight on SIRT1/PGC1/Nrf2/HO1 axis

However, it also have potential side effects which must be considered

Pyruvate is the final product of glycolysis and the initial organic acid that enters the TCA cycle of respiration, while malate and succinate are key intermediates in the TCA cycle for the generation of reductants and adenosine triphosphate (ATP) (Akram 2014)

Materials and Methods UGT74F1 and UGT74F2 expression in Escherichia coli Codon optimized genes for UGT74F1 and UGT74F2 were ordered from Genscript and cloned into pET15(+)b with a thrombin-cleavable N-terminal hexa-histidine tag

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