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The reason for this variation is still unknown but may be associated with mutations in the tumor suppressor gene TP53

2015;7:271ra279

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A previous study reported that vitamin C could prevent monosodium iodoacetate (MIA) induced changes such as cell growth inhibiting and oxidative stress increasing, apoptosis, MMPs increasing, and proteoglycan loss in a chondrosarcoma cell line (SW1353) [160]

So theyre typically well-tolerated

The oxidation profile of the GHGHG peptide has a clear additional peak at a potential of ~0.5 V, which corresponds to the oxidation potential of free Cu + (Fig