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This comment is informational and for adult smokers aged 18 only.

Nicotine is very addictive, and even when smoking a few cigarettes a month can lead to an addiction

Although nicotine is highly addictive and people know it is addictive, people still pick up this habit

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Empty boxes mean that no studies are available in this category Figure 3 summarizes the data comparing the toxicity and health impact of IQOS to controls (exposed to air), cigarette smoking, and smoking cessation models, including in vitro, in vivo , and human perspectives