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There were similar rates of mild adverse events (e.g., nausea, restlessness, insomnia, irritability) across groups in trials of cytisine based on our initial overview.22 However, an updated Cochrane review on cytisine42 suggested there may be a small increase in adverse events, which could constitute a small harm (4 RCTs, n = 4052

[45] In the late 19th century, during the peak in popularity of chewing tobacco in the Western United States, a device known as the spittoon was a ubiquitous feature throughout places both private and public (e.g

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