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Mechanistically, tirzepatide treatment led to activation of brain areas that are known to control appetite and feeding behavior in rodents [67], a finding that is consistent with another GLP-1 analogs (semaglutide) activity in the brain [68]

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doi: 10.1074/jbc.271.25.15146

10.1016/j.ogc.2011.05.004 Obstet