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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
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Dajemy Ci elastyczne opcje patnoci
10.1038/s41598-017-09202-4 112 Shekh-AhmadT.EckelR.Dayalan NaiduS.HigginsM.YamamotoM.Dinkova-KostovaA
Awake craniotomy in a patient with previously diagnosed post-traumatic stress disorder
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