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A population impact model of the effects of nicotine replacement therapy (NRT) products, varenicline, and bupropion [2] found that using these recommended methods, just 2.3% of persons who smoke would quit, equaling a reduction in United States (U.S.) population-level smoking prevalence of 0.3%

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DNA adduct formation from metabolic 5-hydroxylation of the tobacco-specific carcinogen N -nitrosonornicotine in human enzyme systems and in rats