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Figure 4 illustrates the antimicrobial mechanisms of polyphenols, illustrating the disruption of microbial cell structures (lipopolysaccharide cell wall, peptidoglycan cell wall, phospholipid bilayers, cell membrane proteins) and the impairment of essential cellular functions (inhibition of DNA gyrase and RNA synthesis, pore formation causing leakage, damage to membrane lipid bilayers, inhibition of enzyme activity, disruption of cell wall biosynthesis, and inactivation of lipopolysaccharide) in bacteria such as S
The SURPASS clinical trial program demonstrated that tirzepatide at its highest dose (15 mg weekly) produced average weight loss of 20-25% of body weight, significantly exceeding the results seen with GLP-1 only agonists
doi: 10.1055/s-0043-117893 77 StamatouliABedoyaPYavuzS
Going from 68 weeks to 104 weeks added only 0.3 percentage points of additional weight loss
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