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Using singlenucleus RNA sequencing, the researchers found that H1 and H2 histamine receptors are enriched in excitatory neurons

But for many people, the challenge begins after stopping them

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Then an endocrinologist asked if he'd like to try one of the new class of glucagon-like peptide-1, or GLP-1, drugs that include Wegovy and Mounjaro

Second, although SGLT2i monotherapy has been linked to improvements in fatty liver index and lower risk of MALO in MASLD patients, 12,15,28,29,30 , our findings suggest that adding GLP-1RA to SGLT2i provided additional hepatic benefits, reducing the risk of MALO by 39%