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Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response ( Figure 2 Macrophages have different phenotypes with different activation pathways that lead to different organismal responses

[8] In later years, Hitler viewed smoking as "decadent" [12] (meaning that it was bad for his health) and "the wrath of the Red Man against the White Man, vengeance for having been given hard liquor"

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doi: 10.1016/s1470-2045(22)00540-x 21