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People taking other medications, such as corticosteroids and psychotropic drugs (such as antidepressants) which can cause weight gain, may also find GLP-1 drugs dont work very well for them
We have learned through conducting phase 3 trials that we can significantly reduce these adverse effects bycounseling on a healthy diet
In T2DM patients, GLP-1 analogs modulated palatable food intake in humans
17 Similarly, in a meta-analysis of 14 RCTs in T2DM patients conducted by Liu et al, tirzepatide was shown to provide superior HbA1c reduction and improved metabolic outcomes compared to placebo, insulin, and all other GLP-1 RAs at all doses examined
L-carnitine also may help reduce lactic acid accumulation and support a higher lactate threshold, but most importantly, it may help reduce mental fatigue