27, gaab042
Research documents its role in metabolic homeostasis, insulin sensitivity, and exercise capacity making it one of the most studied mitochondrial-derived peptides (MDPs)
The SURPASS program, which targeted patients with type 2 diabetes [29, 36,37,38,39,40,41,42], and the SURMOUNT program, which included individuals with obesity but without diabetes [43,44,45], both reported clinically significant reductions in body weight
Yehuda Handelsman: Received research grants, consultant and speaker honoraria from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Corcept, Eli Lilly, Ionis, Merck, Novo Nordisk, Regeneron, Sanofi, Verdiva Bio
Clinically, it manifests as decreased waist and hip girths and altered silhouette
J Vis Exp 75:2609