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Miller et al (9) found that adiponectin can bind to the inducible adiponectin receptor 1 on airway epithelial cells and macrophages, promote the production of IL-8, TNF- and other inflammatory mediators, and recruit the aggregation of various inflammatory cells (shch as macrophages and neutrophils) by chemotaxis

"This means ideally hitting a sweet spot that maximizes getting vaccine into arms while also being mindful of the priority groups -- especially because these are people who are higher risk for complications from COVID-19 or are more likely to be exposed to the virus because of their jobs," Nordlund said

If FDA does not act within such 100 days, the petition shall be deemed to be denied unless an extension is mutually agreed upon by the FDA and the petitioner