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In 2022, just eight years after they were launched as a completely new product to the market, 17.9% of men and 6% of women were using HTP.[3] Meanwhile, the number of Japanese people who smoked fell from 29.7% of men and 9.7% of women in 2016,[4] to 26.5% of men and 7.7% of women in 2022.[5] The success of HTP is unequivocal, but the relatively modest recent fall in smoking prevalence could be explained by independent and industry-sponsored studies that reveal most HTP users in Japan also smoke cigarettes.[6][7] This is important because other research has also found that HTP use allows two-thirds of these dual users to reduce the number of cigarettes they smoke,[8] a fact that could have profound implications for public health in Japan

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These results indicated that the epigenetic mechanism of Bcl-2 promoter methylation is involved in CSE-induced emphysema and lung cell apoptosis

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