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Particularly, PAHs formed during incomplete tobacco combustion influence the hepatic cytochrome P450 (CYP450) enzyme system, especially by induction of isoenzymes CYP1A1, 1A2, 1B1, and 2E1, leading to accelerated drug clearance, potentially lowering blood concentrations
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Misinforming smokers risks discouraging them from using e-cigarettes, which are one of the most effective methods that exist to help people stop smoking.
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