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At present, it is impossible to reach a consensus on the safety of e-cigarettes except perhaps to say that they may be safer than conventional cigarettes but are also likely to pose risks to health that are not present when neither product is used, wrote physicians Chitra Dinakar and George OConner in The New England Journal of Medicine in 2016

Garcia-Rodriguez O, Secades-Villa R, Florez-Salamanca L, Okuda M, Liu SM, Blanco C

Nicotinic acetylcholine receptors may initially deliver beneficial effects, such as improved attention or reduced inflammation, but chronic exposure leads to downregulation and tolerance

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Villares, Cristina Redko, and Jair J