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Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (up to 2.5% reduction) in type 2 diabetes, while weight management trials showed 15-21% weight loss in adults with obesity without diabetes

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TikTok calls it the vacation peptide. The compound is melanotan II, and its more famous nickname, the Barbie drug, has been showing up in dermatology journals since at least 2010 for the tan, plus a side effect serious enough that it later spun off its own FDA-approved libido drug

JACC 82(9):833955 Rangaswami J, Bhalla V, de Boer IH, Staruschenko A, Sharp JA, Singh RR et al (2020) Cardiorenal protection with the newer antidiabetic agents in patients with diabetes and chronic kidney disease: a scientific statement from the American Heart Association