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These agents stimulate glucose-dependent insulin secretion and suppress inappropriate glucagon release, thereby improving glycemic control
Furthermore, GLP-1 RAs not only improve glycaemia but also provide additional benefits such as body weight reduction and protective effects against cardiovascular disease and diabetic kidney disease (DKD), and metabolic dysfunction-associated steatotic liver disease (MASLD)[5,6,7]
HIF-1 then dimerizes with HIF-1, binding to hypoxia-responsive elements (HREs) in target genes, including VEGF
D., Joo, H., Mosberg, H