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Cigarette smoke consists of numerous compounds that are harmful, and it has been linked to a reduction in the thickness of layers in the brain, and to brain lesions, involving areas such as the frontal lobe, which plays a role in voluntary movement and control of thinking, and a decrease in activity in the area of the brain that processes vision, he said

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Taylor KS, Seminowicz DA, Davis KD (2009) Two systems of resting state connectivity between the insula and cingulate cortex