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Treatment stage What may be common What deserves attention Week 1 Nausea, fullness, reduced appetite, bloating, indigestion, diarrhea, constipation, fatigue Repeated vomiting, severe pain, inability to stay hydrated Weeks 2 to 4 Early symptoms may settle, persist, or fluctuate Symptoms interfering with eating, drinking, or daily function Weeks 5 to 8 Symptoms may reappear after clinician-directed dose escalation A significant return or worsening of gastrointestinal symptoms Months 2 to 3 Some patients tolerate treatment more comfortably

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However, we did not observed that knockdown of ER inhibited the expression of MBOAT1 or 2 in MCF-7 cells (data not shown)

IHC, Immunohistochemistry

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The compound Coenzyme Q10 (CoQ10) is an intracellular (meaning present in the cells) antioxidant that supports the health of tissues and organs