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The authors put forward two theories to help explain the association: the self-medication hypothesis, suggesting that adolescents experiencing emotional distress such as loneliness may misperceive nicotine use as helpful in relieving negative feelings or improve mood (see Section 9A.3), and the social facilitation theory, proposing that nicotine use may help adolescents gain acceptance and a sense of belonging within peer groups when facing social exclusion

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The mechanism of the antidepressant effect of exercise is not precisely known, and is likely multi-factorial, with alterations in neurotransmitters, inflammatory cytokines, neuroendocrine pathways, dopamine processing, oxidative stress, neuroplasticity, reward processing, body image, self-efficacy, functional independence, and many other pathways likely operative [455] The dose-response characteristics, such as adequate doses for aerobic exercise [193] and appropriate intensity for PRT [447], indicate that its benefits stem from biological mechanisms rather than merely the effects of attention or socialization