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When combined with a consistent exercise routine, dihydroberberine supplementation has demonstrated remarkable synergistic effects: The combination of GlucoVantage and exercise led to a substantial 22.7% reduction in fat content compared to exercise alone , while simultaneously supporting a 15.7% increase in lean body mass

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The metabolites associated with glycolysis, tricarboxylic acid cycle (TCA cycle), and urea cycle, as well as amino acids and coenzymes did not exhibit clear changes indicating activated metabolic pathways (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, Zychma M, Blonde L LEAD-6 Study Group

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