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Smoking is related to CRP levels in a doseresponse manner, and smoking cessation reduces CRP levels, but only after at least 1 year [38, 39]

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Interestingly, the nicotine levels found in the samples from e-cigarette users were very similar to those who used NRT and to smokers

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Step 1: systematic review approach to literature search and data extraction Informed by the systematic review approach we took for the GBD 2019 (ref