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Numerous studies have indicated that the Mediterranean diet correlates with reduced expression of proinflammatory pathways and increased expression of neuroprotective pathways [47,47,48]

The essential role of IGFs in cell growth is shown by the report that fibroblasts from IGF-1 receptor knockout mice grew very slowly in culture unless they were transfected with a plasmid expressing the IGF-1 receptor

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Response of IGF-1 to nutritional support in malnourished hospital patients: a possible indicator changes in nutritional status

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Collectively, these findings establish a mechanistic pathway whereby LEO restores dysregulated SCFA production in diabetic mice, highlighting dose-responsive butyrate accumulation as the dominant effector mediating enhanced GLP-1 secretion in functionally compromised enteroendocrine cells