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Health minister Jean-Yves Duclos said: Tobacco use continues to be one of Canada's most significant public health problems, and is the country's leading preventable cause of disease and premature death in Canada

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Respir Res (2009) 10:108.10.1186/1465-9921-10-108 37 BrandsmaCAKerstjensHAMvan GeffenWHGeerlingsMPostmaDSHylkemaMNet alDifferential switching to IgG and IgA in active smoking COPD patients and healthy controls