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Graduated Dosing Strategies Research protocols that minimize side effects often employ graduated dosing approaches: Start Low, Go Slow : Beginning with minimal effective doses and gradually increasing based on individual tolerance and response

Likewise, ligamentous instability and malalignment can exacerbate stresses parallel to the articular surface, increasing shear forces experienced by the implant and repair tissue

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10 mg in 2 mL gives 5,000 mcg/mL