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Studies using single oral doses of metformin hydrochloride tablets 500 mg to 1500 mg, and 850 mg to 2550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination

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Clinical improvements are typically observed within 812 weeks, with optimal results seen over 36 months depending on severity and compliance

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Given the medication's appetite-suppressing effects, maximizing nutritional value in smaller portions becomes essential to prevent deficiencies while supporting metabolic health