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Nicotine replacement therapy (NRT) Although co-administration of varenicline (1 mg twice daily) and transdermal nicotine (21 mg/day) for up to 12 days did not affect nicotine pharmacokinetics, the incidence of nausea, headache, vomiting, dizziness, dyspepsia, and fatigue was greater for the combination than for NRT alone

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Stop Smoking You can utilize nicotine replacement therapy, counseling, and drugs where needed

This suggests that cigarette smoking, as well as cessation, can impact drug metabolism (Maideen, 2019)