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We highlight how excessive mtROS contribute to oxidative damage, mitochondrial dysfunction, impaired energy metabolism, and activation of key atrophy-related signaling pathways, including FOXO, NF-B, MAPK, the ubiquitin-proteasome system, and the autophagy-lysosome pathway

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Reduced gastric volume and altered anatomy mean standard GLP-1 doses produce stronger satiety and gastric-slowing effects