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Improvements in childhood hygiene have meant that fewer people acquire HSV-1 as children, leaving more young adults seronegative when they begin sexual activity

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John Snow was able to draw in London in 1854 between an outbreak of cholera among the inhabitants of Golden Square, in the borough of Marylebone, and a pump, on Broad Street, from which the families of the victims had been drawing their drinking water

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This means whether you are an experienced smoker, or a beginner is important