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In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 17,18,19,20,21,22

Guo R, Xu W, Wang Y, Yue L, Huang S, Xiu Y, et al

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ViiV backed the supplemental application with data from the DANCE study, which evaluated Dovato in treatment-naive adolescents, along with evidence from well-controlled studies in adults