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The siRNA sequences targeting SLC7A11, GCLC, and GSS were synthesized by Genepharma (Suzhou, China)

JAK inhibitors (tofacitinib, upadacitinib) offer oral convenience, whereas monoclonal antibodies (influx, miikizumab) are more advantageous in terms of mucosal healing and long-term remission

Generalization to clinical populations, including special populations, such as patients with iron-deficiency anemia, pregnant or postmenopausal women, and persons with nutritional deficiencies, should also be made with caution

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If taking multiple times daily, reduce to once daily for one week